Amnion injections for joint pain

Amnion Injections

We can enhance the natural healing of soft tissues such as tendons and ligaments through targeted injections of human amniotic membrane.
A Rich Source of Healing Factors

The amnion is the innermost layer of the placenta. In human medicine, it is ethically sourced only through live cesarean deliveries, and amnion injections are FDA-regulated. Amnion cells offer a multipotent mix of natural factors that promote tissue healing better than any synthetic drug. For many years, amnion cells have been reduced to films used by surgeons to ensure wound healing and minimal scarring. At Primary Spine & Rehab, amnion cells have been converted to an injectable solution. A clinician uses ultrasound guidance to precisely inject a small amount of the amnion solution where healing is needed. Many chronic pain conditions such as tennis elbow (epicondylosis), heel spurs (plantar fasciosis), shoulder impingement (rotator cuff tendinosis), etc. result from the body's failed healing response in areas with limited blood flow. Amnion injections have been shown to improve even the most treatment-resistant tendon and ligament disorders with only one shot.

Conditions Treated
Research shows amnion injections to be effective for a variety of tendon/ligament/joint pain conditions. Amnion injections can be used for any soft-tissue lesion where a targeted, enhanced healing response would be desired. Examples include:
How Amnion Works
The injectable solution contains 226 different growth factors, cytokines, and chemokines including interleukins. These agents provide core building blocks for tissue repair. They also influence the body's natural healing response to direct your own stem cells and other tissue building blocks to the area. Some of the agents manage inflammation naturally. The improved healing response reduces adhesions. This means your healing tissues lay down in more functional useful patterns, so recovery is faster and more complete.
The Treatments

Physical therapy and other treatments may be recommended, but most of the research showing the effectiveness of amnion injections involves only one shot. A clinician will use ultrasound imaging to know exactly where your lesion is located and exactly where the needle is placed. In other types of therapies, injections performed without ultrasound guidance have been shown to be less effective. Then the solution will be injected.

This type of treatment goes by many names. We refer to it here using the the general term amnion injection. Scientific literature often uses the generic term dehydrated amnion/chorion membrane (dHACM) allografts. Competing laboratories produce amnion injectables, some with different advantages, each with different trade names. Trade names for amnion injections include AmnioFix®, Amnioflo®, BioRenew®, PTM Therapy®, etc.

Obtaining Amnion Cells

Not to be confused with embryonic stem cells, amnionic cells give us most of the regenerative factors and properties of stem cells with non-controversial collection only through healthy ceasarean deliveries. For medical treatments, federal law prohibits the use of cells collected by any means other than live birth. For millennia, humanity has simply discarded amnionic material from birth. In the 21st century, medical science is finally coming to understand the healing factors in the human body and the value of healing factors that can be derived from amniotic material. The practice of regenerative medicine studies how to use this science and help the body heal itself.



Regenerative medicine treatments give us an important advantage in the resolution of joint pain, muscle pain, and certain types of arthritis. If you are experiencing these conditions, please contact us now.
Research Sources
  1. Lei J, Priddy LB, Lim JJ, Koob TJ. Dehydrated Human Amnion/Chorion Membrane (dHACM) Allografts as a Therapy for Orthopedic Tissue Repair. Techniques in Orthopaedics. 2017 May 19.
  2. Gellhorn A, Han A. The use of dehydrated human amnion/chorion membrane allograft injection for the treatment of tendinopathy or arthritis: a case series involving 40 patients. PM&R. 2017.
  3. Werber B. Amnionic tissues for the treatment of chronic plantar fasciosis and Achilles tendinosis. Journal of Sports Medicine. 2015; Article ID 219896
  4. Aufiero D, Sampson S, Onish K, Bemden B. Treatment of medial and lateral elbow tendinosis with an injectable amnionic membrane allograft - a retrospective case series. Journal of Pain Relief. 2016; 5 (3): 1000242.
  5. Weinman J, Broner T. Dehydrated human amnion/chorion membrane (dHACM) injectable for lower extremity tendinopathies. Desert Foot. 2014.
  6. Creaney L, et al. Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective double-blind, randomized trial of autologous blood injections versus platelet-rich plasma injections. Br J Sports Med. 2011;45:966-71.
  7. Koob TJ, Rennert R, Zabek N, Massee M, Lim JJ, Temenoff JS, Li WW, Gurtner G. Biological properties of dehydrated human amnion/chorion composite graft: implications for chronic wound healing. Int Wound J. 2013 Aug 1. doi: 10.1111/iwj.12140.
  8. Zelen CM, Poka A, Andrews J. Prospective, randomized, blinded, comparative study of injectable micronized dehydrated amniotic/chorionic membrane allograft for plantar fasciitis--a feasibility study. Foot Ankle Int. 2013 Oct;34(10):1332-9.
  9. Willett NJ, Thote T, Lin AS, Moran S, Raji Y, Sridaran S, Stevens HY, Guldberg RE. Intra-articular injection of micronized dehydrated human amnion/chorion membrane attenuates osteoarthritis development. Arthritis Research & Therapy. 2014 Feb 6;16(1):R47.